منابع مشابه
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, a 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3-driven generation of insulin-producing β cells, resembling that observed during pancre...
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Mangiferin, a xanthonoid found in plants including mangoes and iris unguicularis, was suggested in previous studies to have anti-hyperglycemic function, though the underlying mechanisms are largely unknown. This study was designed to determine the therapeutic effect of mangiferin by the regeneration of β-cells in mice following 70% partial pancreatectomy (PPx), and to explore the mechanisms of ...
متن کاملCan UPR integrate fasting and stem cell regeneration?
In order to find ways to counter massive loss of regeneration and self-renewal that the stem cells (SCs) suffer from following chemotherapy, the cancer biologists have set foot in regenerative medicine. A significant breakthrough in this direction, made by Dr. Longo’s group situated at University of Southern California, has demonstrated that cycles of prolonged fasting (72 h and more) and refee...
متن کاملExperimental models of β-cell regeneration
The control of glucose metabolism by pancreatic endocrine cells throughout life relies on a tight regulation of the mass of insulin-producing beta-cells. How this homoeostasis is achieved is not well understood. Over the last few years, experimental rodent models with altered beta-cell mass, and, more recently, new transgenic approaches designed to tackle this problem, have provided abundant in...
متن کاملRegeneration of the pancreatic β cell
Type 1 diabetes is the result of an autoimmune attack against the insulin-producing β cells of the endocrine pancreas. Current treatment for patients with type 1 diabetes typically involves a rigorous and invasive regimen of testing blood glucose levels many times a day along with subcutaneous injections of recombinant DNA–derived insulin. Islet transplantation, even with its substantially impr...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2017
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2017.28